For the study of the liver metabolic functions in several liver diseases the hepatic venous blood and the peripheral venous blood were drawn by means of the hepatic vein catheterization technique. The test subjects were 7 normal cases. 14 cases of .liver cirrhosis, 10 cases of clonrchiasis. On the other hand, 6 dogs weighing 10-18kg were experimentally subjected to clonorchiasis by infesting metacereariaes Follow-up studies were done 4 and 8 months after the infestation. All subjects were put into the basal metabolic state by fasting 18 to 20 hours before the experiment. Number of observations totaled 43.
1. Blood sugar levels;
In normal subjects the blool sugar levels of the hepatic vein was higher thann that of the peripheral vein. However in liver cirrhosis and clonorchis sinensis infested dogs, the blood sugar level of the I peripheral vein was higher: It is inferable from these results that the liver under-the basal` meatabolic°´ state is the source of the blood sugar, and, under the pathological state, controls the blood sugar level.
2. The plasma total protein and plasma albumin values in normal subjects were higher in the peripheral venous blood, while the plasma globulin values was contrarily higher in the,hepatic venous blood. However, in liver cirrhosis, some of clonorchiasis, and in the experimentally infested. animals, the results were reversed. The latter cases were in moderately advanced clinical stage. It appears. that the liver maintains the dynamic ´balance between the plasma protein and the tissue protein.
3. The plasma total cholesterol and cholesteroll ester levels were higher in the peripheral venous blood of the normal subjects, however, most cases of liver cirrhosis and some of clonorchiasis showed the reverse results.
4. The blood ammonia levels were lower in the peripheral vein in normal subjects, however, in liver Cirrhosis, the level was notonly elevated but on the contrarily higher in the hepatic vein. There were no specific changes observed in the experimental animals.
5.The serum´bilirubin levels were higher in the peripheral venous blood in normal subjects, while in liver cirrhosis, some of clonorchiasis, and in the infested animals, the levels werenot only elevated in total-but especially in the hepatic vein: This. suggests that,bilirubin is mainly produced in the extra hepatic-reticuloendothelial system.
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